Hydrogen Bromide → HCID 13487107, compound

HRID 1975413Notes

Reaction equation

HRID 1975413 reaction equation
[ClH:1].C[O:3][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][C@H:8]([N:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])[C@@H:9]2[CH3:14].Br>CO>[ClH:1].[OH:3][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][C@H:8]([N:15]([CH2:16][CH2:17][CH3:18])[CH2:19][CH2:20][CH3:21])[C@@H:9]2[CH3:14]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 13487103HCID 13487103, compound

Product 1

HCID 13487107HCID 13487107, compoundYield 72.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(-)-cis-5-Methoxy-1-methyl-2-(di-n-propylamino)tetralin hydrochloride (0.37 g, 0.0012 mol) was treated with 48% HBr (15 ml) as described above to give (-)-cis-5-hydroxy-1-methyl-2-(di-n-propylamino)tetralin hydrochloride (0.26 g, 55%) m.p. 228°-229° C., [α]D22 =-50.1 (c=1.1, CH3OH).

Sources & evidence

ORD record
ord-b2680bcd1dc74f398ef6e7420af435dc
Source dataset
uspto-grants-1994_02
Patent number
US05286747

Reaction notes

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