反应详情

To a suspension of 0.013 g of lithium aluminum hydride in 5.0 ml of tetrahydrofuran is added 0.100 g of methyl 2-butyl-1,4-dihydro-4-oxo-6-quinazolinecarboxylate followed by stirring at room temperature for 5 hours. An additional 20 mg of lithium aluminum hydride is added and stirring continued for 18 hours. An additional 20 mg of lithium aluminum hydride is added and stirring continued for an additional 8 hours. The reaction mixture is poured into 75 ml of water and extracted with ethyl acetate. The extract is evaporated in vauco to a residue which is stirred with acetone and filtered to give 0.040 g of the desired product as a white solid.

1. stirringstirring
2. waitcontinued for 18 hours
3. stirringstirring
4. waitcontinued for an additional 8 hours
5. extractionextracted with ethyl acetate
6. customThe extract is evaporated in vauco to a residue which
7. stirringis stirred with acetone
8. filtrationfiltered