Chloroform → HCID 19099228, compound

HRID 1975467Notes

Reaction equation

HRID 1975467 reaction equation
F[C:2](F)(F)[C:3]([OH:5])=O.[C:8]([CH2:10][C:11]1[NH:12][CH:13]=[CH:14][N:15]=1)#[N:9].C(Cl)(Cl)[Cl:17]>C(O)C>[ClH:17].[ClH:17].[NH:12]1[CH:13]=[CH:14][N:15]=[C:11]1[CH2:10][C:8](=[NH:9])[O:5][CH2:3][CH3:2]

Participants

4

Reactant 2

HCID 6212ChloroformHCID 19099231HCID 19099231, compound

Product 1

HCID 19099228HCID 19099228, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into the suspension of 2-cyanomethylimidazole trifluoroacetate (7 g) in a mixture of chloroform (25 ml) and ethanol (2.42 ml) was absorbed hydrogen chloride gas (2.54 g) at 0° C. The resulting mixture was allowed to stand at 0° C. for 7 days. The residue was triturated with diisopropyl ether to give ethyl 2-(imidazol-2-yl)-acetimidate dihydrochloride (6.28 g).

Workup

  1. customwas absorbed hydrogen chloride gas (2.54 g) at 0° C
  2. customThe residue was triturated with diisopropyl ether

Sources & evidence

ORD record
ord-4c30c5f121014a3098a4f8278a1f810f
Source dataset
uspto-grants-1994_02
Patent number
US05286721

Reaction notes

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