反应详情

温度

80 °C

The mixture of 3-chloromethyl-2-methylpyridine (9.2 g) and sodium cyanide (9.55 g) in dimethyl sulfoxide (80 ml) was stirred for 30 minutes at 80° C. The reaction mixture was poured into a mixture of water (200 ml) and ethyl acetate (1 l). Organic layer was separated, washed with brine and dried over magnesium sulfate. Concentration of the solvent gave a residue, which was chromatographed on silica gel (300 ml) eluting with a mixture of hexane and ethyl acetate (1:4, V/V) to give 3-cyanomethyl-2-methylpyridine (7.6 g).

1. customOrganic layer was separated
2. washwashed with brine
3. dry with materialdried over magnesium sulfate
4. customConcentration of the solvent gave a residue, which
5. customwas chromatographed on silica gel (300 ml)
6. washeluting with a mixture of hexane and ethyl acetate (1:4, V/V)