M-Cresol → 2-Propanamine, 1-(3-methylphenoxy)-

HRID 1975535Notes

Reaction equation

HRID 1975535 reaction equation
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:8].[CH3:9][CH:10]1[NH:12][CH2:11]1>CCCCCCCCCC>[CH3:8][C:2]1[CH:1]=[C:6]([CH:5]=[CH:4][CH:3]=1)[O:7][CH2:9][CH:10]([NH2:12])[CH3:11]

Participants

4

Reactant 2

HCID 342M-CresolHCID 63772-Methylaziridine

Product 1

HCID 122988962-Propanamine, 1-(3-methylphenoxy)-Yield 57.5%

Reagents, catalysts & solvents 1

HCID 15600DecaneSolvent

Procedure

21.6 Grams (0.20 mol) of m-cresol and 2.3 g (0.04 mol) of propyleneimine in 20 ml of n-decane were allowed to react in an autoclave at 5 kg/cm2G at 150° C. for 6 hours. Thereafter, the resultant reaction product was treated in the same manner as in Example 17 to give 3.8 g of 1-(3-methylphenoxy)-2-propylamine. Its yield was as high as 57%.

Workup

  1. customto react in an autoclave at 5 kg/cm2G at 150° C. for 6 hours
  2. customThereafter, the resultant reaction product
  3. additionwas treated in the same manner as in Example 17

Sources & evidence

ORD record
ord-e5b23485237f42d0aab5b0b75f82fc8f
Source dataset
uspto-grants-1994_02
Patent number
US05286905

Reaction notes

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