HCID 53638921, compound → HCID 86747587, compound

HRID 1975598Notes

Reaction equation

HRID 1975598 reaction equation
[NH2:1]/[C:2](/[CH3:22])=[CH:3]\[C:4]([O:6][CH2:7][CH:8]=[CH:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17]2[NH:18][CH:19]=[CH:20][N:21]=2)=[CH:12][CH:11]=1)=[O:5].[F:23][C:24]([F:41])([F:40])[C:25]1[CH:26]=[C:27]([CH:37]=[CH:38][CH:39]=1)[CH:28]=[C:29]([C:34]([CH3:36])=O)[C:30]([O:32][CH3:33])=[O:31]>C1(C)C=CC=CC=1>[CH3:22][C:2]1[NH:1][C:34]([CH3:36])=[C:29]([C:30]([O:32][CH3:33])=[O:31])[CH:28]([C:27]2[CH:37]=[CH:38][CH:39]=[C:25]([C:24]([F:23])([F:40])[F:41])[CH:26]=2)[C:3]=1[C:4]([O:6][CH2:7]/[CH:8]=[CH:9]/[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17]2[NH:21][CH:20]=[CH:19][N:18]=2)=[CH:12][CH:11]=1)=[O:5]

Participants

4

Reactant 2

HCID 53638921HCID 53638921, compoundHCID 867475833-[4-(1-Imidazolylmethyl)phenyl]-2-propen-1-yl 3-aminocrotonate

Product 1

HCID 86747587HCID 86747587, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

297 mg (1 mM) of 3-{4-(1-imidazolylmethyl)phenyl}-2-propen-1-yl 3-aminocrotonate and 272 mg (1mM) of methyl 2-(3-trifluoromethylbenzylidene)acetoacetate were dissolved in 5 ml of toluene and refluxed for six hours. After cooling, the crystals produced were filtered off and recrystallized from methanol, whereby the captioned compound was obtained. The yield was 394 mg (71.5%).

Workup

  1. temperaturerefluxed for six hours
  2. temperatureAfter cooling
  3. customthe crystals produced
  4. filtrationwere filtered off
  5. customrecrystallized from methanol, whereby the captioned compound
  6. customwas obtained

Sources & evidence

ORD record
ord-9c640a5fff5e49c2afc1a5b1e40e9863
Source dataset
uspto-grants-1994_02
Patent number
US05286869

Reaction notes

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