反应详情

温度

70 °C

A mixture of 9 g of methyl 3-(3-cyclohexenyl)-5-chlorosalicylate and 20 ml trifluoroacetic acid is heated at 70° C. overnight. The cooled reaction mixture is diluted with hexanes, washed three times with water, dried and evaporated to dryness. The residue is purified with flash chromatography using 10% ethyl acetate/hexane to give four fractions. First fraction 2.29 of material (mixture of at least two materials); second fraction 2.29 cis isomer; third fraction 1.69 mixture of cis and trans isomers; and fourth fraction 19 trans isomer.

1. customThe cooled reaction mixture
2. washwashed three times with water
3. customdried
4. customevaporated to dryness
5. customThe residue is purified with flash chromatography
6. customto give four fractions
7. additionFirst fraction 2.29 of material (mixture of at least two materials)
8. additionthird fraction 1.69 mixture of cis and trans isomers