Hydrogen Bromide → HCID 19098308, compound

HRID 1975683Notes

Reaction equation

HRID 1975683 reaction equation
C([NH:11][CH2:12][C:13]([NH:15][C:16]1[S:17][C:18]([S:21]([NH2:24])(=[O:23])=[O:22])=[N:19][N:20]=1)=[O:14])(OCC1C=CC=CC=1)=O.[BrH:25].C(OCC)C>C(O)(=O)C>[BrH:25].[NH2:11][CH2:12][C:13]([NH:15][C:16]1[S:17][C:18]([S:21]([NH2:24])(=[O:23])=[O:22])=[N:19][N:20]=1)=[O:14]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 15041392HCID 15041392, compound

Product 1

HCID 19098308HCID 19098308, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

The desired compound is prepared by subjecting 2-(N-carbobenzyloxyglycylamino)-1,3,4-thiadiazole-5-sulfonamide (0.5 gram) suspended in glacial acetic acid (5 ml) to a solution of hydrogen bromide in glacial acetic acid (32% w/w, 8.0 ml) at room temperature for 1 hour with stirring. Diethyl ether (50 ml) is then added and the mixture set aside for three hours at 0° C. The solid precipitate is collected, washed with diethyl ether, and dried to give the desired product, 2-(glycylamino)-1,3,4-thiadiazole-5-sulfonamide hydrobromide, m.p. 207°-209° C. (0.4 gram).

Workup

  1. customThe desired compound is prepared
  2. customThe solid precipitate is collected
  3. washwashed with diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-eaba8f970aa142d19c7a7d5d5c0d5856
Source dataset
uspto-grants-1994_02
Patent number
US05288735

Reaction notes

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