Hydrogen Bromide → HCID 19098304, compound

HRID 1975685Notes

Reaction equation

HRID 1975685 reaction equation
C([NH:11][CH2:12][C:13]([N:15]=[C:16]1[N:20]([CH3:21])[N:19]=[C:18]([S:22]([NH2:25])(=[O:24])=[O:23])[S:17]1)=[O:14])(OCC1C=CC=CC=1)=O.[BrH:26].C(OCC)C>C(O)(=O)C>[BrH:26].[NH2:11][CH2:12][C:13]([N:15]=[C:16]1[N:20]([CH3:21])[N:19]=[C:18]([S:22]([NH2:25])(=[O:23])=[O:24])[S:17]1)=[O:14]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 19098302HCID 19098302, compound

Product 1

HCID 19098304HCID 19098304, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

The desired compound is prepared by subjecting 2-(N-carbobenzyloxy-glycylimino)-3-methyl-1,3,4-thiadiazoline-5-sulphonamide (0.5 gm) suspended in glacial acetic acid (5ml) to a solution of hydrogen bromide in glacial acetic acid (32% w/w. 8.0 ml) at room temperature for about 1 hour with stirring. Diethyl ether (50 ml) is then added and the mixture set aside for three hours at 0° C. The solid precipitate is collected, washed with diethyl ether, and dried to give the desired product, 2-(glycylimino)-3-methyl-1,3,4-thiadiazoline-5-sulphonamide hydrobromide, m.p. 209°-210° C. (0.4 gm).

Workup

  1. customThe desired compound is prepared
  2. customThe solid precipitate is collected
  3. washwashed with diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-5695bd4e776042699bebcd000ce4d90a
Source dataset
uspto-grants-1994_02
Patent number
US05288735

Reaction notes

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