HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 4-(Pyridin-2-ylmethoxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | N-acetyl-4-(pyrid-2-ylmethoxy)aniline | HCID 19098335 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(Pyridin-2-ylmethoxy)aniline | HCID 10442773 | — |
Reaction Steps
A suspension of N-acetyl-4-(pyrid-2-ylmethoxy)aniline (116 g; 480 mmol), prepared as in step 1, in 1000 mL 95% ethanol and 130 mL 10M aqueous KOH was refluxed for 2 days. The reaction was concentrated and diluted with water. The mixture was extracted with ethyl acetate. The extracts were dried over magnesium sulfate and concentrated to give 4-(pyrid-2-ylmethoxy)aniline as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05288743 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-981d6e0103a24384920d019ea54fc202 |
| Source note | uspto-grants-1994_02 |