HCID 178524364, compound → HCID 178527211, compound

HRID 1975824Notes

Reaction equation

HRID 1975824 reaction equation
C([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][S:17]([C:19]2[NH:20][C:21]3[CH:26]=[CH:25][N:24]=[CH:23][C:22]=3[N:27]=2)=[O:18])[CH:11]=1)(=O)C1C=CC=CC=1>[OH-].[NH4+]>[NH:20]1[C:21]2[CH:26]=[CH:25][N:24]=[CH:23][C:22]=2[N:27]=[C:19]1[S:17]([CH2:16][C:12]1[CH:11]=[C:10]([OH:9])[CH:15]=[CH:14][CH:13]=1)=[O:18]

Participants

3

Reactant 1

HCID 178524364HCID 178524364, compound

Product 1

HCID 178527211HCID 178527211, compound

Reagents, catalysts & solvents 1

HCID 14923Ammonium HydroxideSolvent

Procedure

3-[(1H-Imidazo[4,5-c]pyridin-2-ylsulfinyl)methyl]phenol benzoate (ester) (2.65 g, 0.007 mol) was dissolved in 260 mL of ammonium hydroxide. The reaction mixture was stirred for 1 1/2 hours at room temperature. The ammonia was removed in a rotary evaporator and the reaction mixture was chilled in ice. The precipitate that formed was collected on a filter and rinsed with water giving 1.70 g of product. (m.p. 224°-227° C.) (dec.).

Workup

  1. customThe ammonia was removed in a rotary evaporator
  2. temperaturethe reaction mixture was chilled in ice
  3. customThe precipitate that formed
  4. customwas collected on
  5. filtrationa filter
  6. washrinsed with water giving 1.70 g of product

Sources & evidence

ORD record
ord-f81cfdba828743368198832160537ff1
Source dataset
uspto-grants-1994_02
Patent number
US05288871

Reaction notes

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