Iodoethane → HCID 178477485, compound

HRID 1975902Notes

Reaction equation

HRID 1975902 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]([NH2:17])=[S:16])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:18][CH2:19][CH3:20]>CC(C)=O>[IH:18].[CH2:19]([S:16][C:15](=[NH:17])[NH:14][C:11]1[CH:12]=[CH:13][C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:9][CH:10]=1)[CH3:20]

Participants

4

Reactant 2

HCID 6340IodoethaneHCID 27603494-Phenoxyphenylthiourea

Product 1

HCID 178477485HCID 178477485, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a stirred solution of 1-(4-phenoxyphenyl)-2-thiourea (2.00 g, 8.19 mmol) in acetone (20 ml) was added iodoethane (7.61 g, 48.7 mmol). The mixture was heated to reflux for three hours, cooled to room temperature and concentrated at reduced pressure. The resulting viscous oil was crystallized from acetone-pentane to afford S-ethyl-N-(4-phenoxyphenyl)isothiourea hydroiodide as a beige solid. Mp=140-143° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for three hours
  3. concentrationconcentrated at reduced pressure
  4. customThe resulting viscous oil was crystallized from acetone-pentane

Sources & evidence

ORD record
ord-bc9406f2ad1d4b459e5b1ff78e25e25c
Source dataset
uspto-grants-2001_05
Patent number
US06225305B1

Reaction notes

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