(1-Isothiocyanatoethyl)benzene → HCID 11588885, compound

HRID 1975923Notes

Reaction equation

HRID 1975923 reaction equation
Cl.[NH2:2][C:3]1[CH:7]=[C:6]([Cl:8])[S:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10].[CH3:13][CH:14]([N:21]=[C:22]=[S:23])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[NH2:2][C:3]1[CH:7]=[C:6]([Cl:8])[S:5][C:4]=1[S:9]([NH:12][C:22]([NH:21][C@@H:14]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH3:13])=[S:23])(=[O:10])=[O:11]

Participants

3

Reactant 2

HCID 20559(1-Isothiocyanatoethyl)benzeneHCID 688206263-Amino-5-chlorothiophene-2-sulfonamide hydrochloride

Product 1

HCID 11588885HCID 11588885, compound

Procedure

The title compound was prepared from 3-amino-5-chlorothiophene-2-sulfonamide hydrochloride and D-α-methylbenzyl isothiocyanate by a procedure analogous to the procedure described in example 3-a (yield 96% impure product); 1H-NMR (DMSO-d6): δ1.46 (d, 3H, CH3), 5.36 (quint, 1H, CH), 6.45 (br s, 2H, NH2), 6.64 (s, 1H, H-4), 7.2-7.4 (m, 5H, ArH), 8.53 (br d, 1H, NH), 11.3 (br s, 1H).

Sources & evidence

ORD record
ord-f9a09af0a0124517818652f610e727c5
Source dataset
uspto-grants-2001_05
Patent number
US06225310B1

Reaction notes

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