Hydrochloric Acid → n-(3,5-Bis-trifluoromethyl-benzyl)-n-methyl-3-o-tolyl-isonicotinamide hydrochloride

Participants

Reaction Steps

To a solution of 440 mg N-(3,5-bis-trifluoromethyl-benzyl)-N-methyl-3-o-tolyl-isonicotinamide in 5 ml diethyl ether were added 5 ml 3 N hydrochloric acid solution in diethyl ether. After stirring for 10 min at room temperature, the solution was evaporated to dryness, dissolved in 3 ml diethyl ether and stirred for 1 h at −10° C. Filtration of the suspension afforded 376 mg (79%) of the title compound as white crystals. M.p. 186-188° C.

Provenance & Evidence