反应详情

To a solution of 440 mg N-(3,5-bis-trifluoromethyl-benzyl)-N-methyl-3-o-tolyl-isonicotinamide in 5 ml diethyl ether were added 5 ml 3 N hydrochloric acid solution in diethyl ether. After stirring for 10 min at room temperature, the solution was evaporated to dryness, dissolved in 3 ml diethyl ether and stirred for 1 h at −10° C. Filtration of the suspension afforded 376 mg (79%) of the title compound as white crystals. M.p. 186-188° C.

1. customthe solution was evaporated to dryness
2. dissolutiondissolved in 3 ml diethyl ether
3. stirringstirred for 1 h at −10° C
4. filtrationFiltration of the suspension