HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → Ethyl 2-(4-methylpiperazin-1-yl)pyridine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Ethyl 2-chloroisonicotinate | HCID 2762942 | — |
| Product | Ethyl 2-(4-methylpiperazin-1-yl)pyridine-4-carboxylate | HCID 2762483 | 50% |
Reaction Steps
A solution of 5.56 g (30 mmol) 2-chloro-isonicotinic acid ethyl ester in 20 ml 1-methylpiperazine was heated for 5 hrs at 90° C. The solvent was evaporated and the residue purified by chromatography to give 3.72 g (50%) of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225316B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-905bd170a4374e3b92b4fe20bf2d5aad |
| Source note | uspto-grants-2001_05 |