1-Methylpiperazine → Ethyl 2-(4-methylpiperazin-1-yl)pyridine-4-carboxylate

HRID 1975953Notes

Reaction equation

HRID 1975953 reaction equation
[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][N:8]=[C:7](Cl)[CH:6]=1)[CH3:2].[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([N:17]2[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]2)[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 2762942Ethyl 2-chloroisonicotinate

Product 1

HCID 2762483Ethyl 2-(4-methylpiperazin-1-yl)pyridine-4-carboxylateYield 50%

Procedure

A solution of 5.56 g (30 mmol) 2-chloro-isonicotinic acid ethyl ester in 20 ml 1-methylpiperazine was heated for 5 hrs at 90° C. The solvent was evaporated and the residue purified by chromatography to give 3.72 g (50%) of the title compound as a yellow oil.

Workup

  1. customThe solvent was evaporated
  2. customthe residue purified by chromatography

Sources & evidence

ORD record
ord-905bd170a4374e3b92b4fe20bf2d5aad
Source dataset
uspto-grants-2001_05
Patent number
US06225316B1

Reaction notes

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