6-Chloro-2,3-dihydro-1h-indole → 4-(6-Chloro-2,3-dihydro-indol-1-yl)-6-phenyl-quinazoline

HRID 1975978Notes

Reaction equation

HRID 1975978 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[CH:12][NH:11][C:10]3=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:18][C:19]1[CH:27]=[C:26]2[C:22]([CH2:23][CH2:24][NH:25]2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:27]=[C:26]2[C:22]([CH2:23][CH2:24][N:25]2[C:10]2[C:9]3[C:14](=[CH:15][CH:16]=[C:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[CH:8]=3)[N:13]=[CH:12][N:11]=2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 2585676-Chloro-2,3-dihydro-1h-indoleHCID 1357413026-Phenylquinazolin-4(3H)-one

Product 1

HCID 220001084-(6-Chloro-2,3-dihydro-indol-1-yl)-6-phenyl-quinazoline

Procedure

The title compound was prepared in a manner analogous in the method of Example 4 using 6-Phenyl-3H-quinazolin-4-one (250 mg, 1.124 mmol) and 6-chloroindoline (172 mg, 1.124 mmol)). Three hundred eighty-nine milligrams (88%) of a yellow solid was isolated from the reaction mixture.

Sources & evidence

ORD record
ord-8970a41501074764ad2367d19b632b4f
Source dataset
uspto-grants-2001_05
Patent number
US06225318B1

Reaction notes

Loading…