6-Chloro-2,3-dihydro-1h-indole → 4-(6-Chloro-2,3-dihydro-indol-1-yl)-7-methoxy-6-phenyl-quinazoline

HRID 1975979Notes

Reaction equation

HRID 1975979 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7](=O)[NH:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[Cl:20][C:21]1[CH:29]=[C:28]2[C:24]([CH2:25][CH2:26][NH:27]2)=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:29]=[C:28]2[C:24]([CH2:25][CH2:26][N:27]2[C:7]2[C:6]3[C:11](=[CH:12][C:3]([O:2][CH3:1])=[C:4]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:5]=3)[N:10]=[CH:9][N:8]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 2585676-Chloro-2,3-dihydro-1h-indoleHCID 1358153167-Methoxy-6-phenyl-3H-quinazolin-4-one

Product 1

HCID 220001294-(6-Chloro-2,3-dihydro-indol-1-yl)-7-methoxy-6-phenyl-quinazoline

Procedure

The title compound was prepared from 7-Methoxy-6-phenyl-3H-quinazolin-4-one (250 mg, 0.99 mmol) and 6-chloroindoline (152 mg, 0.99 mmol) utilizing the method of Example 45 (163 mg, 39%). One hundred sixty-three milligrams (39%) of product was obtained after column chromatography and precipitation as the HCl salt.

Sources & evidence

ORD record
ord-f89f10f76974429da45e40d01c48e472
Source dataset
uspto-grants-2001_05
Patent number
US06225318B1

Reaction notes

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