HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-2,3-dihydro-1h-indole → 4-(6-Chloro-2,3-dihydro-indol-1-yl)-7-methoxy-6-phenyl-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-2,3-dihydro-1h-indole | HCID 258567 | — |
| Reactant | 7-Methoxy-6-phenyl-3H-quinazolin-4-one | HCID 135815316 | — |
| Product | 4-(6-Chloro-2,3-dihydro-indol-1-yl)-7-methoxy-6-phenyl-quinazoline | HCID 22000129 | — |
Reaction Steps
The title compound was prepared from 7-Methoxy-6-phenyl-3H-quinazolin-4-one (250 mg, 0.99 mmol) and 6-chloroindoline (152 mg, 0.99 mmol) utilizing the method of Example 45 (163 mg, 39%). One hundred sixty-three milligrams (39%) of product was obtained after column chromatography and precipitation as the HCl salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225318B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-f89f10f76974429da45e40d01c48e472 |
| Source note | uspto-grants-2001_05 |