HCID 70246168, compound → HCID 20651504, compound

HRID 1975983Notes

Reaction equation

HRID 1975983 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[CH2:18][CH2:17][C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[CH:10]([CH:19]3[CH2:24][CH2:23][N:22]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:21][CH2:20]3)[C:7]2=[N:8][CH:9]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[CH2:18][CH2:17][C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[CH:10]([CH:19]3[CH2:24][CH2:23][N:22]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:21][CH2:20]3)[C:7]2=[N:8][CH:9]=1

Participants

5

Reactant 2

HCID 70246168HCID 70246168, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20651504HCID 20651504, compoundYield 89.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Ethyl 4-(3-nitro-6,11-dihydro-5H-cyclohepta[2,1-b:4,5- b′]dipyridin-11-yl)-1-piperidinecarboxylate ( 0.14gm, 0.367 mmol) was dissolved in 15 ml of ethanol. Palladium/carbon (10%, 20 mg) was added and the reaction mixture hydrogenated at 50 psi of hydrogen for 2 hours. The palladium was filtered and the ethanol evaporated to give 0.12 gm of the title product. FABMS (M+1)=367

Workup

  1. filtrationThe palladium was filtered
  2. customthe ethanol evaporated

Sources & evidence

ORD record
ord-f4d38900be3b4399afc61b79f63470ca
Source dataset
uspto-grants-2001_05
Patent number
US06225322B1

Reaction notes

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