2-Naphthalenesulfonyl chloride → HCID 22721786, compound

HRID 1975991Notes

Reaction equation

HRID 1975991 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)=[O:15])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][C:23]=1[S:32](Cl)(=[O:34])=[O:33]>CN(C=O)C>[CH:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][C:23]=1[S:32]([N:19]1[CH2:18][CH2:17][N:16]([C:14](=[O:15])[CH2:13][N:10]2[CH2:9][CH2:8][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:12][CH2:11]2)[CH2:21][CH2:20]1)(=[O:33])=[O:34]

Participants

4

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 22721946HCID 22721946, compound

Product 1

HCID 22721786HCID 22721786, compoundYield 22%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using an analogous procedure to that described in Example 2 except that DMF was used in place of methylene chloride as the reaction solvent, 1-{2-[4-(4-pyridyl)piperazin-1-yl]acetyl}piperazine was reacted with 2-naphthylsulphonyl chloride to give 1-(2-naphthylsulphonyl)-4-{2-[4-(4-pyridyl)piperazin-1-yl]acetyl}-piperazine in 22% yield;

Sources & evidence

ORD record
ord-51cb1becd8214a998b7340ce42e8287d
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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