1-(4-Pyridyl)piperazine → HCID 22721860, compound

HRID 1976004Notes

Reaction equation

HRID 1976004 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][CH2:15][C:16]([NH:18][CH2:19][CH2:20][CH2:21][C:22](O)=[O:23])=[O:17])(=[O:13])=[O:12].[N:25]1[CH:30]=[CH:29][C:28]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[CH:27][CH:26]=1>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][CH2:15][C:16]([NH:18][CH2:19][CH2:20][CH2:21][C:22]([N:34]1[CH2:33][CH2:32][N:31]([C:28]2[CH:29]=[CH:30][N:25]=[CH:26][CH:27]=2)[CH2:36][CH2:35]1)=[O:23])=[O:17])(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 705171-(4-Pyridyl)piperazineHCID 22721896HCID 22721896, compound

Product 1

HCID 22721860HCID 22721860, compoundYield 21%

Procedure

Using an analogous procedure to that described in Example 18, 4-[2-(2-naphthalenesulphonamido)acetamido]butyric acid was reacted with 1-(4-pyridyl)piperazine to give 2-(2-naphthalenesulphonamido)-N-{3-[4-(4-pyridyl)piperazin-1-ylcarbonyl]propyl}acetamide in 21% yield as a foam;

Sources & evidence

ORD record
ord-29da8f9e49494b09af9a585e8891aa73
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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