1-(4-Pyridyl)piperazine → HCID 22721795, compound

HRID 1976012Notes

Reaction equation

HRID 1976012 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[S:23]([N:26]1[CH2:31][CH2:30][CH2:29][CH:28]([C:32](O)=[O:33])[CH2:27]1)(=[O:25])=[O:24]>>[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[S:23]([N:26]1[CH2:31][CH2:30][CH2:29][CH:28]([C:32]([N:10]2[CH2:9][CH2:8][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:12][CH2:11]2)=[O:33])[CH2:27]1)(=[O:24])=[O:25]

Participants

3

Reactant 2

HCID 705171-(4-Pyridyl)piperazineHCID 31536341-(Naphthalen-2-ylsulfonyl)piperidine-3-carboxylic acid

Product 1

HCID 22721795HCID 22721795, compoundYield 25%

Procedure

Using an analogous procedure to that described in Example 14, 1-(4-pyridyl)piperazine was reacted with 1-(2-naphthylsulphonyl)piperidine-3-carboxylic acid to give 1-[1-(2-naphthylsulphonyl)-piperidin-3-ylcarbonyl]-4-(4-pyridyl)piperazine as a foam in 25% yield;

Sources & evidence

ORD record
ord-09fe02502bd84c9da64142e1584e4ae5
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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