2-Naphthalenesulfonyl chloride → ethyl 1-naphthalen-2-ylsulfonylpiperidine-3-carboxylate

HRID 1976013Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:2]1.[CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[S:22](Cl)(=[O:24])=[O:23]>>[CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[S:22]([N:1]1[CH2:6][CH2:5][CH2:4][CH:3]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:2]1)(=[O:23])=[O:24]

Participants

Reactant 2

HCID 71252-Naphthalenesulfonyl chloride

HCID 98969Ethyl nipecotate

Product 1

HCID 3785564ethyl 1-naphthalen-2-ylsulfonylpiperidine-3-carboxylateYield 62%

Procedure

Using an analogous procedure to that described in Example 2, ethyl piperidine-3-carboxylate was reacted with 2-naphthylsulphonyl chloride to give ethyl 1-(2-naphthylsulphonyl)piperidine-3-carboxylate in 62% yield.

Sources & evidence

ORD record: ord-f7c6bad792804e6996e7bf24622f8e6e
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06225309B1

Reaction notes

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