Piperazine → 1-(3-Bromobenzenesulfonyl)piperazine

HRID 1976022Notes

Reaction equation

HRID 1976022 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Br:7][C:8]1[CH:9]=[C:10]([S:14](Cl)(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=1>>[Br:7][C:8]1[CH:9]=[C:10]([S:14]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 17943m-Bromobenzenesulphonyl chloride

Product 1

HCID 24052531-(3-Bromobenzenesulfonyl)piperazine

Procedure

Using analogous procedures to those described in the portion of Example 58 which is concerned with the preparation of starting materials, piperazine was reacted with 3-bromophenylsulphonyl chloride to give 1-(3-bromophenylsulphonyl)piperazine which, in turn, was reacted with 3,5-dichlorophenylboronic acid to give 1-(3′,5′-dichlorobiphenyl-3-ylsulphonyl)piperazine in 29% yield;

Sources & evidence

ORD record
ord-3b407b2ae1334481872cc7da50229682
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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