4'-Bromobiphenyl-4-sulfonyl chloride → HCID 22721817, compound

HRID 1976039Notes

Reaction equation

HRID 1976039 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([C:13]([C:15]3[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=3)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[Br:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:34]=[CH:33][C:32]([S:35]([Cl:38])(=[O:37])=[O:36])=[CH:31][CH:30]=2)=[CH:25][CH:24]=1>>[ClH:38].[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:8][CH2:9][N:10]([C:13]([C:15]3[CH:21]=[CH:20][C:18]([NH:19][S:35]([C:32]4[CH:31]=[CH:30][C:29]([C:26]5[CH:27]=[CH:28][C:23]([Br:22])=[CH:24][CH:25]=5)=[CH:34][CH:33]=4)(=[O:36])=[O:37])=[CH:17][CH:16]=3)=[O:14])[CH2:11][CH2:12]2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 27568454'-Bromobiphenyl-4-sulfonyl chlorideHCID 22721904HCID 22721904, compound

Product 1

HCID 22721817HCID 22721817, compoundYield 90%

Procedure

Using an analogous procedure to that described in Example 89, 4-[4-(4-pyridyl)piperazin-1-ylcarbonyl]aniline was reacted with 4′-bromo-4-biphenylylsulphonyl chloride to give N-{4-[4-(4-pyridyl)piperazin-1-ylcarbonyl]phenyl}-4′-bromo-4-biphenylylsulphonamide hydrochloride salt in 90% yield, m.p. 201-205° C.;

Sources & evidence

ORD record
ord-ac48079824894d8b9493eab391ad2d3b
Source dataset
uspto-grants-2001_05
Patent number
US06225309B1

Reaction notes

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