反应详情

2-Hydroxy-5-nitropyridine (10.0 g, 71 mmol) in chloroform (200 ml) and acetic acid (10 ml) was treated with bromine (3.7 ml, 72 mmol) and then refluxed for 24 hrs. More bromine (3.7 ml, 72 mmol) was added and the mixture refluxed for a further 48 hrs, then cooled. Ethyl acetate (150 ml) was added and the solid formed removed by filtration, washed with ethyl acetate (50 ml) and dried to give the product as an off-white powder (8.5 g).

1. temperaturerefluxed for 24 hrs
2. temperaturethe mixture refluxed for a further 48 hrs
3. temperaturecooled
4. customthe solid formed
5. customremoved by filtration
6. washwashed with ethyl acetate (50 ml)
7. customdried