Bromine → 4-Bromo-5-methoxy-2-(trifluoromethyl)pyridine

HRID 1976071Notes

Reaction equation

HRID 1976071 reaction equation
[Br:1]Br.[CH3:3][O:4][C:5]1[C:6]([Sn](C)(C)C)=[N:7][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:10]=1>ClCCl>[Br:1][C:10]1[CH:9]=[C:8]([C:11]([F:14])([F:13])[F:12])[N:7]=[CH:6][C:5]=1[O:4][CH3:3]

Participants

4

Reactant 2

HCID 24408BromineHCID 22000199HCID 22000199, compound

Product 1

HCID 220001724-Bromo-5-methoxy-2-(trifluoromethyl)pyridine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from bromine (0.21 ml, 4 mmol) and a solution of 3-methoxy-6-trifluoromethyl-2-trimethylstannylpyridine (0.7 g, 2.0 mmol) in dichloromethane (10 ml) according to the method of Description 42 to afford 4-bromo-3-methoxy-6-trifluoromethylpyridine as a yellow solid.

Sources & evidence

ORD record
ord-4fdbbc75c7944e7ba613954fef208938
Source dataset
uspto-grants-2001_05
Patent number
US06225320B1

Reaction notes

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