Hydrochloric Acid → HCID 22000244, compound

HRID 1976151Notes

Reaction equation

HRID 1976151 reaction equation
C1O[C:4]2([CH2:9][CH2:8][N:7]([C:10]3[CH:15]=[CH:14][N:13]=[CH:12][N:11]=3)[CH2:6][CH2:5]2)[O:3]C1.Cl>CC(C)=O>[N:13]1[CH:14]=[CH:15][C:10]([N:7]2[CH2:6][CH2:5][C:4](=[O:3])[CH2:9][CH2:8]2)=[N:11][CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21833565HCID 21833565, compound

Product 1

HCID 22000244HCID 22000244, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The 1-(pyrimidin-4-yl)-4-piperidone ethylene ketal was dissolved in acetone (25 ml) and 1 N HCl (25 ml) was stirred for 18 hr. The acetone was removed in vacuo and the mixture made basic with saturated sodium carbonate. The mixture was extracted twice with ethyl acetate. The extracts were combined, dried with brine, and concentrated in vacuo to give 1-(pyrimidin-4-yl)-4-piperidone as a white powder (0.80 g, 51.4% for two steps, mp: 61-65° C.).

Workup

  1. customThe acetone was removed in vacuo
  2. extractionThe mixture was extracted twice with ethyl acetate
  3. dry with materialdried with brine
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5ce8c44af00a47e4b654ec43237efc97
Source dataset
uspto-grants-2001_05
Patent number
US06225324B1

Reaction notes

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