L-Hydroxyproline → HCID 28157465, compound

HRID 1976220Notes

Reaction equation

[OH:1][C@H:2]1[CH2:6][NH:5][C@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1.F[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N+:17]([O-:19])=[O:18]>>[OH:1][C@H:2]1[CH2:6][N:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N+:17]([O-:19])=[O:18])[C@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1

Participants

Reactant 2

HCID 5810L-Hydroxyproline

HCID 738951-Fluoro-2-nitrobenzene

Product 1

HCID 28157465HCID 28157465, compoundYield 71.1%

Procedure

The same procedures used in Reference Example 1 were repeated except for using trans-4-hydroxy-L-proline and 1-fluoro-2-nitrobenzene to give the title compound. Yield 71.1%.

Sources & evidence

ORD record: ord-d78e15967c704b788c59c20991953292
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06225306B1

Reaction notes

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