1-(2-Nitrophenyl)-L-proline → ZINC00251459

HRID 1976224Notes

Reaction equation

HRID 1976224 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:17][CH2:16][CH2:15][C@H:11]1[C:12](O)=[O:13])([O-])=O>[C].[Pd].CO>[CH2:17]1[N:10]2[C:5]3[C:4]([NH:1][C:12](=[O:13])[C@@H:11]2[CH2:15][CH2:16]1)=[CH:9][CH:8]=[CH:7][CH:6]=3

Participants

4

Reactant 1

HCID 281193991-(2-Nitrophenyl)-L-proline

Product 1

HCID 770113ZINC00251459Yield 83.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

The 1-(2-nitrophenyl)-L-proline (1.56 g) obtained in Reference Example 1 was catalytically reduced at ordinary temperature, in the presence of 0.6 g of a 10% palladium-carbon catalyst, in 150 ml of methanol. After completion of the reaction, the catalyst was removed and then the reaction solution was concentrated to dryness to give 1.04 g (yield 83.3%) of the title compound.

Workup

  1. customAfter completion of the reaction
  2. customthe catalyst was removed
  3. concentrationthe reaction solution was concentrated to dryness

Sources & evidence

ORD record
ord-beca15ac9cae4d7cb2f087c8a599dff0
Source dataset
uspto-grants-2001_05
Patent number
US06225306B1

Reaction notes

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