Lithium Hydroxide → HCID 44337391, compound

Participants

Reaction Steps

Methyl (S)-2,3,4,5-tetrahydro-7-[[[(benzimidazol-2-yl)methyl]amino]carbonyl]-3-oxo-1H-1,4-benzodiazepine-2-acetate is hydrolyzed with 1M LiOH to yield the title compound (66%) as a white powder: [α]n25 −145.3° (c=1, CH3OH); MS (ES) m/e 394.2 (M+H)+. Anal. Calcd for C20H19N5O4.2 TFA.0.125 H2O: C, 46.22; H, 3.43; N, 11.23. Found: C, 46.13; H, 3.78; N, 11.49.

Provenance & Evidence