Lithium Hydroxide → HCID 44337391, compound

HRID 1976267Notes

Reaction equation

[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[CH2:10][NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]2[NH:23][C@@H:22]([CH2:24][C:25]([O:27]C)=[O:26])[C:21](=[O:29])[NH:20][CH2:19][C:18]=2[CH:30]=1)=[O:13].[Li+].[OH-]>>[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[CH2:10][NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]2[NH:23][C@@H:22]([CH2:24][C:25]([OH:27])=[O:26])[C:21](=[O:29])[NH:20][CH2:19][C:18]=2[CH:30]=1)=[O:13]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 54076272HCID 54076272, compound

Product 1

HCID 44337391HCID 44337391, compoundYield 66%

Procedure

Methyl (S)-2,3,4,5-tetrahydro-7-[[[(benzimidazol-2-yl)methyl]amino]carbonyl]-3-oxo-1H-1,4-benzodiazepine-2-acetate is hydrolyzed with 1M LiOH to yield the title compound (66%) as a white powder: [α]n25 −145.3° (c=1, CH3OH); MS (ES) m/e 394.2 (M+H)+. Anal. Calcd for C20H19N5O4.2 TFA.0.125 H2O: C, 46.22; H, 3.43; N, 11.23. Found: C, 46.13; H, 3.78; N, 11.49.

Sources & evidence

ORD record: ord-be2ed33a16b44fc59d1eb3f812b53e3c
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06225465B1

Reaction notes

Loading…