HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2,2,2-Trichloroethyl 4-(2,3,5-trimethylphenoxy)butyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trichloroethanol | HCID 8259 | — |
| Reactant | 4-(2,3,5-Trimethylphenoxy)butanoic acid | HCID 14492659 | — |
| Reactant | 1-(3-Dimethylaminopropyl)ethylcarbodiimide hydrochloride | HCID 21982921 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2,2,2-Trichloroethyl 4-(2,3,5-trimethylphenoxy)butyrate | HCID 22000915 | — |
Reaction Steps
A mixture of 4-(2,3,5-trimethylphenoxy)butyric acid (4.82 mg) dimethylaminopyridine (DMAP, 0.26 g), 2,2,2-trichloroethanol (2.50 ml), 1-(3-dimethylaminopropyl)ethylcarbodiimide hydrochloride (4.57 g) and CH2Cl2 was stirred at room temperature overnight. The reaction mixture was poured into a mixture of AcOEt and water. The separated AcOEt was washed with dil. HCl, sat. NaHCO3, water, and brine, and dried over MgSO4, and then evaporated to give 2,2,2-trichloroethyl 4-(2,3,5-trimethylphenoxy)butyrate (8.11 g) as an oil compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06225480B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-b6296ef4325640a78ae35397a2d59229 |
| Source note | uspto-grants-2001_05 |