反应详情

A mixture of 4-(2,3,5-trimethylphenoxy)butyric acid (4.82 mg) dimethylaminopyridine (DMAP, 0.26 g), 2,2,2-trichloroethanol (2.50 ml), 1-(3-dimethylaminopropyl)ethylcarbodiimide hydrochloride (4.57 g) and CH2Cl2 was stirred at room temperature overnight. The reaction mixture was poured into a mixture of AcOEt and water. The separated AcOEt was washed with dil. HCl, sat. NaHCO3, water, and brine, and dried over MgSO4, and then evaporated to give 2,2,2-trichloroethyl 4-(2,3,5-trimethylphenoxy)butyrate (8.11 g) as an oil compound.

1. washThe separated AcOEt was washed with dil. HCl, sat. NaHCO3, water, and brine
2. dry with materialdried over MgSO4
3. customevaporated