反应详情

A mixture of methyl 1-({[4-(2-butynyloxy)phenyl]sulfonyl}amino)cyclohexanecarboxylate (4.5 g.,12.3 mmol), anhydrous potassium carbonate (20.0 g, excess) and methyl iodide (2 g, 14.08 mmol) was refluxed in acetone for sixteen hours. The reaction mixture was then cooled to room temperature and filtered. The acetone layer was concentrated and extracted with chloroform. The chloroform layer was washed well with water, dried over anhydrous MgSO4, filtered and concentrated to provide methyl1-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]cyclohexanecarboxylate as a yellow oil. Yield: 4.6 g(quantitative) Electrospray Mass Spec 380 (M+H)+.

1. filtrationfiltered
2. concentrationThe acetone layer was concentrated
3. extractionextracted with chloroform
4. washThe chloroform layer was washed well with water
5. dry with materialdried over anhydrous MgSO4
6. filtrationfiltered
7. concentrationconcentrated