Lithium iodide → HCID 13127852, compound

HRID 1976485Notes

Reaction equation

C(OC(NCCCCC#CCOC1C=CC=CC=1S([N:26]1[CH2:31][CH2:30][S:29][C:28]([CH3:33])([CH3:32])[CH:27]1[C:34]([O-:36])=[O:35])(=O)=O)=O)(C)(C)C.[I-].[Li+]>>[CH3:32][C:28]1([CH3:33])[S:29][CH2:30][CH2:31][NH:26][CH:27]1[C:34]([OH:36])=[O:35]

Participants

Reactant 2

HCID 66321Lithium iodide

HCID 131722542HCID 131722542, compound

Product 1

HCID 13127852HCID 13127852, compound

Procedure

The methyl ester of methyl (3 S}[4 {[({7-[(tert-butoxycarbonyl)amino]-2-heptynyl}oxy)phenyl]sulfonyl}-2,2-dimethyl-3-thiomorpholine carboxylate was converted into the analogous carboxylic acid using lithium iodide according to the procedure of Example 250 to provide (3 S)-4-{[4-{7-[(tert-butoxycarbonyl)amino]-2-heptynyl)oxy)phenyl]sulfonyl}-2,2- dimethyl-3-thiomorpholine carboxylic acid as a white solid Electrospray Mass Spec: 541.2(M+H)+

Sources & evidence

ORD record: ord-b4b1bc3e0d4c4a189f8c938bf24ecea0
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06225311B1

Reaction notes

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