反应详情

According to the procedure of Step 2 of Example 248, Mitsunobu coupling of 2.5 g (6.46 mmol) of tert-butyl (3S)-4-[(4-hydroxyphenyl)sulfonyl]-2,2-dimethyl-3-thiomorpholinecarboxylate and 0.667 g (7.752 mmol) of 2-butyne-1,4-diol gave 1.42 g of tert-butyl (3 S)-4-({4-[(4-hydroxy-2-butynyl)oxy]phenyl)sulfonyl)-2,2-dimethyl-3-thiomorpholine carboxylate as a colorless oil.