反应详情

At 5° C., 59.1 g (0.81 mol) of tert-butylamine were added dropwise to a solution of 118.3 g (0.4 mol) of crude dimethyl chlorosulfonylterephthalate (from Example A1) in 500 ml of dichloromethane, and the mixture was stirred at room temperature for another 1 h. The reaction solution was washed with water, dried and concentrated. Trituration of the crude product with heptane gave 106.7 g (81% of theory) of dimethyl tert-butylsulfamoylterephthalate of m.p. 132-134° C.

1. washThe reaction solution was washed with water
2. customdried
3. concentrationconcentrated