Tert-Butylamine → HCID 21998546, compound

HRID 1976524Notes

Reaction equation

HRID 1976524 reaction equation
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].Cl[S:7]([C:10]1[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[CH:17]=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13])(=[O:9])=[O:8]>ClCCl>[C:1]([NH:5][S:7]([C:10]1[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[CH:17]=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13])(=[O:9])=[O:8])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 384430080998-70-5

Product 1

HCID 21998546HCID 21998546, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

At 5° C., 59.1 g (0.81 mol) of tert-butylamine were added dropwise to a solution of 118.3 g (0.4 mol) of crude dimethyl chlorosulfonylterephthalate (from Example A1) in 500 ml of dichloromethane, and the mixture was stirred at room temperature for another 1 h. The reaction solution was washed with water, dried and concentrated. Trituration of the crude product with heptane gave 106.7 g (81% of theory) of dimethyl tert-butylsulfamoylterephthalate of m.p. 132-134° C.

Workup

  1. washThe reaction solution was washed with water
  2. customdried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-a194ca524e2349ba9f41d3d6ac34d053
Source dataset
uspto-grants-2001_05
Patent number
US06228808B1

Reaction notes

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