Sodium Hydroxide → HCID 21998540, compound

HRID 1976525Notes

Reaction equation

HRID 1976525 reaction equation
[OH-].[Na+].[C:3]([NH:7][S:8]([C:11]1[CH:20]=[C:19]([C:21]([O:23]C)=[O:22])[CH:18]=[CH:17][C:12]=1[C:13]([O:15]C)=[O:14])(=[O:10])=[O:9])([CH3:6])([CH3:5])[CH3:4]>O.CO>[C:3]([NH:7][S:8]([C:11]1[CH:20]=[C:19]([C:21]([OH:23])=[O:22])[CH:18]=[CH:17][C:12]=1[C:13]([OH:15])=[O:14])(=[O:9])=[O:10])([CH3:6])([CH3:4])[CH3:5]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 21998546HCID 21998546, compound

Product 1

HCID 21998540HCID 21998540, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

At 50° C., 45.0 g (1.13 mol) of sodium hydroxide in 600 ml of water were added dropwise to a solution of 106.0 g (0.32 mol) of dimethyl tert-butylsulfamoylterephthalate in 1600 ml of methanol. The mixture was stirred at reflux temperature for 2 h and evaporated, the residue was taken up in approximately 500 ml of water and a pH of 1 was established using conc. hydrochloric acid. The precipitated solid was filtered off with suction and dried. This gave 87.4 g (90% of theory) of tert-butylsulfamoylterephthalic acid of m.p. 210-213° C.

Workup

  1. temperatureat reflux temperature for 2 h
  2. customevaporated
  3. filtrationThe precipitated solid was filtered off with suction
  4. customdried

Sources & evidence

ORD record
ord-0ebb70ce1a744f05b200b8df3d85e3e4
Source dataset
uspto-grants-2001_05
Patent number
US06228808B1

Reaction notes

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