Sodium Hydroxide → HCID 21998540, compound

Participants

Reaction Steps

At 50° C., 45.0 g (1.13 mol) of sodium hydroxide in 600 ml of water were added dropwise to a solution of 106.0 g (0.32 mol) of dimethyl tert-butylsulfamoylterephthalate in 1600 ml of methanol. The mixture was stirred at reflux temperature for 2 h and evaporated, the residue was taken up in approximately 500 ml of water and a pH of 1 was established using conc. hydrochloric acid. The precipitated solid was filtered off with suction and dried. This gave 87.4 g (90% of theory) of tert-butylsulfamoylterephthalic acid of m.p. 210-213° C.

Provenance & Evidence