HCID 21998544, compound → HCID 11141109, compound

HRID 1976527Notes

Reaction equation

HRID 1976527 reaction equation
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]([C:19](=[O:24])[NH:20][CH:21]([CH3:23])[CH3:22])[CH:16]=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12])(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[CH:21]([NH:20][C:19]([C:17]1[CH:16]=[CH:15][C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([S:6](=[O:8])(=[O:7])[NH2:5])[CH:18]=1)=[O:24])([CH3:23])[CH3:22]

Participants

3

Reactant 1

HCID 21998544HCID 21998544, compound

Product 1

HCID 11141109HCID 11141109, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

At room temperature, 19.6 g (0.055 mol) of methyl 2-tert-butylsulfamoyl-4-isopropylcarbamoylbenzoate were stirred in 200 ml of trifluoroacetic acid for 3 h. The mixture was concentrated and the residue was triturated with diethyl ether and filtered off. This gave 15.6 g (95% of theory) of methyl 4-isopropylcarbamoyl-2-sulfamoylbenzoate of m.p. 203-205° C.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was triturated with diethyl ether
  3. filtrationfiltered off

Sources & evidence

ORD record
ord-46e113ce2a974503826c2ce3f4c231e9
Source dataset
uspto-grants-2001_05
Patent number
US06228808B1

Reaction notes

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