HCID 22965801, compound → Ethyl tetrahydropyran-4-ylacetate

HRID 1976570Notes

Reaction equation

HRID 1976570 reaction equation
[O:1]1[CH2:6][CH2:5][C:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:3][CH2:2]1>C(OCC)(=O)C>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 22965801HCID 22965801, compound

Product 1

HCID 2773412Ethyl tetrahydropyran-4-ylacetateYield 100.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 15.0 and 16.0 (3 g, 17.6 mmol) from Preparative Example 10 was dissolved in 20 mL of ethyl acetate containing 1.0 g of 10% paladium on carbon. This mixture was stirred for 18 hours under an atmosphere of hydrogen. The catalyst was filtered and the filtrate was concentrated under vacuum giving 3.04 g of the title product as a colorless oil.

Workup

  1. filtrationThe catalyst was filtered
  2. concentrationthe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-2bc241d07a5b4b86bd33dc7f339d71ec
Source dataset
uspto-grants-2001_05
Patent number
US06228865B1

Reaction notes

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