反应详情

A mixture of methyl-6-methylsulfanyl-1H-indole-2-carboxylate (11.2 g, 51 mmol) and 2N NaOH (125 ml) was heated to reflux temperature for 30 minutes. The clear solution was cooled, and extracted with EtOAc. The aqueous fraction was acidified with concentrated HCl to pH=1, and the precipitate which formed, was filtered and dried to give 6-Methylsulfanyl-1H-indole-2-carboxylic acid (9.6 g, 91.0%).

1. temperaturewas heated
2. temperatureto reflux temperature for 30 minutes
3. temperatureThe clear solution was cooled
4. extractionextracted with EtOAc
5. customthe precipitate which formed
6. filtrationwas filtered
7. customdried