HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 6-(methylsulfanyl)-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 202584-20-1 | HCID 4715405 | — |
| Product | 6-(methylsulfanyl)-1H-indole-2-carboxylic acid | HCID 3907173 | 91% |
Reaction Steps
A mixture of methyl-6-methylsulfanyl-1H-indole-2-carboxylate (11.2 g, 51 mmol) and 2N NaOH (125 ml) was heated to reflux temperature for 30 minutes. The clear solution was cooled, and extracted with EtOAc. The aqueous fraction was acidified with concentrated HCl to pH=1, and the precipitate which formed, was filtered and dried to give 6-Methylsulfanyl-1H-indole-2-carboxylic acid (9.6 g, 91.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06228877B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-496beb0490f54e3eaf4c7848af5695b0 |
| Source note | uspto-grants-2001_05 |