HCID 21906498, compound → (6-trifluoroacetylamino-1-methyl-1H-indol-3-yl)-oxo-acetyl chloride

HRID 1976737Notes

Reaction equation

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:12](=[O:17])[C:13]([F:16])([F:15])[F:14])[CH:9]=2)[CH:4]=[CH:3]1.[C:18](Cl)(=[O:22])[C:19]([Cl:21])=[O:20].C(Cl)Cl>CCOCC>[F:16][C:13]([F:14])([F:15])[C:12]([NH:11][C:8]1[CH:9]=[C:10]2[C:5]([C:4]([C:18](=[O:22])[C:19]([Cl:21])=[O:20])=[CH:3][N:2]2[CH3:1])=[CH:6][CH:7]=1)=[O:17]

Participants

Conditions

Temperature: 0 °C

Procedure

200 mg of 1-methyl-6-trifluoroacetylaminoindole was taken into 5 mL ether and cooled to 0° C. It was treated with 0.485 mL 2.0 M oxalyl chloride/methylene dichloride and stirred at 0° C. for 2 h. The yellow crystals were collected and washed with ether and dried in vacuo to yield 240 mg of (6-trifluoroacetylamino-1-methyl-1H-indol-3-yl)-oxo-acetyl chloride.

Workup

customThe yellow crystals were collected
washwashed with ether
customdried in vacuo

Sources & evidence

ORD record: ord-a8200d21b8b249c785a4d4de3b95bcfd
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06228877B1

Reaction notes

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