Acetic Acid → 2-Amino-1-(3,4,5-trimethoxyphenyl)ethanol

HRID 1976767Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1976767
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH:6]=[O:7].[N+:15]([CH3:18])([O-])=O.[OH-].[Na+].C(O)(=O)C>C(O)C>[OH:7][CH:6]([C:5]1[CH:8]=[C:9]([O:13][CH3:14])[C:10]([O:11][CH3:12])=[C:3]([O:2][CH3:1])[CH:4]=1)[CH2:18][NH2:15]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 6375NitromethaneHCID 68583,4,5-TrimethoxybenzaldehydeHCID 14798Sodium Hydroxide

Produkt 1

HCID 288942-Amino-1-(3,4,5-trimethoxyphenyl)ethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 3,4,5-trimethoxybenzaldehyde (10 g, 51 mmol) and nitromethane (10 mL) in ethanol at 0° C. was treated with 10% sodium hydroxide (21.4 mL, 53.5 mmol), stirred for 45 sesonds, treated with 2% acetic acid (162 mL), stirred for 1 hour in the ice bath, and filtered. The solid was washed with water and dried under vacuum to provide 9.0 g of the desired product as an off-white solid.

Aufarbeitung

  1. filtrationfiltered
  2. washThe solid was washed with water
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-03219068b8ca4d08bb2c339a7afe3a4d
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06228868B1

Notizen zur Reaktion

Wird geladen…