Bromoacetone → HCID 21998742, compound

HRID 1976776Notes

Reaction equation

HRID 1976776 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[Br:12][CH2:13][C:14](=[O:16])[CH3:15]>CC(C)=O>[Br-:12].[O:16]=[C:14]([CH3:15])[CH2:13][N+:3]1[CH:4]=[C:5]([C:6]([O:8][CH3:9])=[O:7])[CH:10]=[CH:11][C:2]=1[CH3:1]

Participants

4

Reactant 2

HCID 11715BromoacetoneHCID 231548Methyl 6-methylnicotinate

Product 1

HCID 21998742HCID 21998742, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of methyl 6-methylnicotinate (1.00 g, 6.60 mmol) and bromoacetone (1.00 g, 7.30 mmol) in acetone (3 mL) was refluxed overnight, cooled to room temperature, and decanted. The resulting solid was dried under vacuum to provide approximatelyl.47 g the desired product as a solid, which was used directly in the next step without further purification.

Workup

  1. customdecanted
  2. customThe resulting solid was dried under vacuum
  3. customto provide approximatelyl
  4. custom47 g the desired product as a solid, which was used directly in the next step without further purification

Sources & evidence

ORD record
ord-ccd3ac7abf5444f6b7100e00f04d69a9
Source dataset
uspto-grants-2001_05
Patent number
US06228868B1

Reaction notes

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