反应详情

A mixture of 1-acetyl-5-bromo-indoline (1.20 g, 5 mmol) and N-chlorosucinimide (0.734 g, 5.5 mmol) in acetonitrile (80 mL) was heated to reflux for 12 hours, cooled to room temperature, and concentrated. The concentrate was purified by flash column chromatography on silica gel to provide 0.548 g of the desired product.

1. temperaturewas heated
2. temperatureto reflux for 12 hours
3. concentrationconcentrated
4. customThe concentrate was purified by flash column chromatography on silica gel